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5-(p-Tolyl)isoxazol-3-amine palladium (II) complex: preparation, structure and catalytic application in Suzuki-Miyaura reaction in water

Vladimir I. Potkin, Nikolay A. Bumagin, Sergey K. Petkevich, Alexander S. Lyakhov, Dmitrii A. Rudakov, Michail V. Livantsov, Nikita E. Golantsov

The air and moisture stable square-planar trans-dichloro palladium (II) complex containing 5-(p-tolyl)isoxazol-3-amine ligand was synthesized and structurally characterized by single crystal X-ray diffraction. The isoxazol-3-amine ligand was prepared from the 5-(p-tolyl)isoxazole-3-carbaldehyde oxime by the series of successive transformations. The new complex is a high-turnover-number catalyst for Suzuki-Miyaura reaction with low Pd loading (0.0001 - 0.1%) in neat water under air atmosphere.

Original Text © Synthesis. 2012. Vol. 44. N 1. P. 151-157.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    

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